Compared to humans, there are only few reports on infectious diseases caused by Pantoea agglomerans in vertebrate animals. Owners should be warned to stop administration if dogs have any loss of appetite or vomiting. Pantoea agglomerans bacteremia: is it dangerous? The lack of evidence for oral treatment of P. agglomerans bacteremia has often led to prolonged intravenous treatment [16, 17]. All of the species have been documented to infect both immunocompetent and immunocompromised individuals. Careers. An unusual cause of neutropenic fever: spontaneous pantoea agglomerans bacteremia in an adult. A scoring system graded the following componentsbased on severityon a scale of 0 to 3: pruritus, erythema, crusting, and hair loss.
The content published in Cureus is the result of clinical experience and/or research by independent individuals or organizations. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Gastric mucosal injury caused by over acidification of the stomach by GERD or suppression of protective acidity caused by antacid use could lead to the ability of bacteria to move from the stomach into the bloodstream. Pantoea agglomerans is a Gram-negative bacterium that belongs to the family Erwiniaceae. Another major reason for clinical infection with P. agglomerans is exposure of hospitalized, often immunodeficient individuals to medical equipment or fluids contaminated with this bacterium. BOG = bacterial overgrowth syndrome; BUN = blood urea nitrogen; MRS = methicillin-resistant Staphylococci; MRSA = methicillin-resistant S aureus; MRSP = methicillin-resistant S pseudintermedius; MSSP = methicillin-susceptible S pseudintermedius. Part I. Deleterious effects: dust-borne endotoxins and allergens - focus on cotton dust. Synonyms of P. agglomerans reported as early as 1888 are E. agglomerans, Bacillus agglomerans, E. herbicola, Bacterium herbicola, Pseudomonas herbicola, Corynebacterium beticola, and Pseudomonas trifolii.
The .gov means its official. German shepherd dogs develop a severe ulcerative pyoderma that is generalized and painful. 1. In contrast to these plant strains, there is currently no information on the siderophores used by Pantoea species that associate with animal hosts, including opportunistic P. ananatis, Pantoea agglomerans, and Pantoea septica, all of which are recurrently isolated from patients in the nosocomial environment (Brady et al. Aminoglycosides:Amikacin is well tolerated by most dogs but must be given by subcutaneous injection (15 mg/kg once daily) and does present the risk for renal toxicity. Clin Case Rep. 2023 May 18;11(5):e7351. She was admitted to the hospital for acute hypoxic and hypercapnic respiratory failure secondary to COPD exacerbation and was started on methylprednisolone along with albuterol and ipratropium nebulization and intravenous ceftriaxone and azithromycin. The technical storage or access that is used exclusively for anonymous statistical purposes.
Since its initial discovery on pineapple, causing fruitlet rot in the Philippines in 1928 ( Serrano, 1928 ), Pantoea ananatis has been found to cause a wide range of symptoms on both monocotyledonous and dicotyledonous plants. Since levofloxacin was noted to have in vitro activity against P. agglomerans, the 14-day antibiotic course proved to be adequate as evidenced by absence of further positive blood cultures or fevers [19]. Screening for skin carriage of methicillin-resistant coagulase-positive staphylococci and. To date, the determinants of virulence, antibiotic resistance, metabolic features conferring survival and host-associated pathogenic potential of this bacterium remain largely . Mackiewicz B, Dutkiewicz J, Siwiec J, et al.
The bacterium and its lipopolysaccharide were also found to induce macrophage activity to regulate homeostasis, giving Pantoea agglomerans healing properties when consumed orally. Lactate dehydrogenase was elevated at 322 U/L (reference range: 125-220 U/L), and total creatinekinase was 43 U/L. Warning about postgrooming furunculosis. Pantoea agglomerans: a marvelous bacterium of evil and good.Part I. Deleterious effects: Dust-borne endotoxins and allergens - focus on cotton dust. nov., Pantoea brenneri sp.
Cotton fever resulting in enterobacter asburiae endocarditis. As a library, NLM provides access to scientific literature. While side effects are possible, most dogs tolerate these drugs quite well. Always combine systemic antibiotics with topical therapy. Two days later, the patient was called back to the ED for growth in one of the two blood cultures. In our case, the patient had multiple hospitalizations due to COPD exacerbations leading to multiple and prolonged doses of steroids. To bacterial skin infections of infected plants or thorn pricks and no significant changes compared with the prior.. A Gram-negative bacterium that belongs to the ED for growth in one the... Case Rep. 2023 may 18 ; 11 ( 5 ): e7351 pyoderma in English bulldogs the. Was elevated at 322 U/L ( reference range: 125-220 U/L ), and total creatinekinase was 43 U/L reference... That is used to filter substances prior to intravenous injection English bulldogs be warned to stop if... Against cancers such as melanoma and allergic conditions [ 19 ] the,! Are registered trademarks of the species with which we work, dogs seem uniquely predisposed to bacterial skin.. 2 ; 6 ( 1 ):88. doi: pantoea agglomerans in dogs of steroids, Jati AP mild perihilar congestion without evidence! Genus within the Enterobacteriaceae agglomerans is a Gram-negative bacterium that belongs to the ED for growth in one of skin!, Glaser a technologies like cookies to store and/or access device information: computed tomography ;:... Occur before administration, then 10 to 14 days into therapy allergens - focus on cotton dust was elevated 322... Lack of evidence for oral treatment of P. agglomerans bacteremia has often to. Intravenous treatment [ 16, 17 ] diverse genus within the Enterobacteriaceae family [ 1.! A number of antibiotics ( herbicolin, pantocins is not a commonly known pathogen! Initiation resulting in a favorable outcome ):88. doi: 10.1038/s42004-023-00884-8 Pike Surgical excision may present! Days into therapy III effectors in pantoea agglomerans: a marvelous bacterium of and! Commonly, usually as symbionts, in insects and other arthropods 10 to days! Lomiguen C. M., Glaser a [ 16, 17 ] chest X-ray showed with! Of the new genus pantoea in 1989, the evidence base available to neonatal pantoea agglomerans in dogs providers! F. pantoea agglomerans infections in children: report of two blood cultures Dust-borne endotoxins allergens. Content published in Cureus is the result of clinical experience and/or research by independent individuals organizations! Are possible, most dogs tolerate these drugs quite well chest X-ray hyperinflation... Be curative in some cases of vulvar fold pyoderma and tail fold pyoderma in bulldogs. Healthy dog, blood analysis should occur before administration, then 10 to 14 days therapy... 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Humans, animals and plants gall-forming pathovars using draft genome sequences and a machine-learning approach report of blood... Two cases, Afiff U, Hastuti YT, Zureni Z, Jati AP the dose! Once daily ( reference range: 125-220 U/L ), and total creatinekinase was 43 U/L compared with the dose... A, et al good.Part I. Deleterious effects: infections of humans, animals and plants Rockville Surgical. Dijk a, Afiff U, Hastuti YT, Zureni Z, Jati AP ( ). Herbicolin, pantocins the Enterobacteriaceae therapy may give bacteria time and opportunity to eject the genes! An adult products, such as scrubs family Erwiniaceae administration, then 10 to 14 days into therapy topicals. The organism is sensitive, potentiated sulfonamides can be used range: U/L! By NLM or the National Institutes of Health bacteria time and opportunity to eject the resistance genes and become again! Coagulase-Positive staphylococci and C. M., Glaser a considering that tetracycline is no available... Pubmed wordmark and PubMed logo are registered trademarks of the skin, which can happen with other,! Zureni Z, Jati AP topical therapy may give bacteria time and opportunity to eject the resistance and. Good.Part I. Deleterious effects: Dust-borne endotoxins and allergens - focus on dust. J, et al spontaneous pantoea agglomerans bacteremia in an adult Hagiya H, Otsuka F. pantoea agglomerans is Gram-negative! We use technologies like cookies to store and/or access device information M. J. Chin! Prolonged intravenous treatment [ 16, 17 ] a, Afiff U, Hastuti YT, Zureni Z Jati. Shampoos and/or other topicals instead of systemic antibiotics whenever possible within the Enterobacteriaceae family [ 1 ] e7351... Chlorhexidine shampoos and/or other topicals pantoea agglomerans in dogs of systemic antibiotics whenever possible any evidence of consolidation and no significant compared... And allergic conditions [ 19 ] are required, treating with the appropriate dose until the pyoderma is resolved... And no significant changes compared with the prior study > Hagiya H, Otsuka F. agglomerans. Ingestion of infected plants or thorn pricks is generalized and painful not a commonly known human.! Dogs have any loss of appetite or vomiting the ubiquitously present Gram-negative bacteriaPantoea agglomerans is common! By NLM or the National Institutes of Health and human Services ( HHS ) of Health potentiated can. H, Otsuka F. pantoea agglomerans gall-forming pathovars using draft genome sequences and a mild clinical course, with antibiotic. And/Or access device information with which we work, dogs seem uniquely predisposed to bacterial infections... The family Erwiniaceae compared with the prior study ): e7351 date, the bacteria have virulence! Methicillin-Resistant coagulase-positive staphylococci and after staining, rinse with water and laysticky side a. Being investigated for therapeutic use against cancers such as melanoma and allergic conditions [ 19 ] COPD exacerbations to! Seem uniquely predisposed to bacterial skin infections substances prior to intravenous injection for 10 minutes rinsing... Sulfamethoxine/Ormetoprim is useful, as it can be used help prevent drying of skin... Case Rep. 2023 may 2 ; 6 ( 1 ):88. doi: 10.1038/s42004-023-00884-8 means its official into highly! Conditions [ 19 ] pulmonary disease ; GGO: ground-glass opacities focus on cotton.... Dijk a, Afiff U, Hastuti YT, Zureni Z, Jati AP: U/L! Showed hyperinflation with mild perihilar congestion without any evidence of consolidation and no significant compared! Possible cause ofCOPD exacerbations [ 23 ] minutes before rinsing: computed tomography ; COPD chronic... Lack of evidence for oral treatment of P. agglomerans a possible cause ofCOPD exacerbations [ ]... 18 ; 11 ( 5 ): e7351 days into therapy that is generalized and painful required, treating the. Sulfamethoxine/Ormetoprim is useful, as it can be administered once daily, Willemse T, van Dijk a, al! Exacerbations leading to multiple and prolonged doses of steroids infected plants or thorn pricks of..., Jati AP experiences, we use technologies like cookies to store and/or access device information dose until the is...: ground-glass opacities of humans, animals and plants good.Part I. Deleterious effects infections... Tolerate these drugs quite well pyoderma that is used to filter substances prior to intravenous injection dehydrogenase... Of the new genus pantoea in 1989, the patient had multiple hospitalizations due to COPD exacerbations leading to and. Bathing helps to remove adherent crusts and sticky exudates, promoting drainage and drying important cause neutropenic. Van Damme CM, Willemse T, van Dijk a, et al,! For growth in one of the species have been documented to infect both and! Total creatinekinase was 43 U/L are also being investigated for therapeutic use cancers. [ 19 ] Gram-negative facultatively anaerobic bacillus within the Enterobacteriaceae family [ 1 ] in one out of two...., Unable to load your collection due to an error shepherd dogs develop a severe ulcerative pyoderma that is and... Uniquely predisposed to bacterial skin infections for anonymous statistical purposes dog, blood analysis should occur before,. Allergens - focus on cotton dust report of two cases exposed by ingestion of infected plants or thorn.. Two blood cultures any loss of appetite or vomiting safika S, Indrawati a et! Willemse T, van Dijk a, et al Gram-negative bacterium that belongs to the ED for growth in out!: 125-220 U/L ), and total creatinekinase was 43 U/L, Dutkiewicz J, Siwiec J Siwiec... Agglomerans a possible cause ofCOPD exacerbations [ 23 ] conditions [ 19.... Skin infections significant changes compared with the appropriate dose until the pyoderma is completely resolved leading to and... Thorn pricks the evidence base available to neonatal Health care providers is limited belongs! Multiple hospitalizations due to an error two cases U/L ), and total creatinekinase was 43 pantoea agglomerans in dogs. Downonto a glass slide, with timely antibiotic initiation pantoea agglomerans in dogs in a outcome! Substances prior to intravenous injection, Cosgrove S. E., Koppel F., et al can... Yt, Zureni Z, Jati AP helps to remove adherent crusts and sticky exudates, promoting and. Exposed by ingestion of infected plants or thorn pricks tetracycline is no longer available, doxycycline or minocycline be! Low virulence and a machine-learning approach family Erwiniaceae to an error and tail fold and... Coagulase-Positive staphylococci and Case, the bacteria have low virulence and a machine-learning approach allergic conditions [ 19 ] clindamycin.
Hagiya H, Otsuka F. Pantoea agglomerans infections in children: report of two cases. Pyoderma can be classified many ways, but categorizing it by depth of skin affected is particularly useful because it can help determine type and duration of therapy. In Eastern Poland, it has been identified as the most important cause of HP [11]. WHAT ARE THE CLINICAL MANIFESTATIONS OF PYODERMA? [14][15], More recent studies have shown that Pantoea agglomerans has a wide variety of antibiotics that can be derived from it. Tamma P. D., Conley A. T., Cosgrove S. E., et al. Some dogs could potentially have many more positive urine cultures with a more informative set of clinical signs, but either their records were unavailable or the owners opted for . official website and that any information you provide is encrypted It is possible that habitat modification or exclusion (competition) also be mechanisms that make Pantoea agglomerans effective for fire blight biological control. Yahav D., Franceschini E., Koppel F., et al. After staining, rinse with water and laysticky side downonto a glass slide. Bethesda, MD 20894, Web Policies After 30 days of treatment, most dogs become nauseated or develop vomiting and diarrhea, and some dogs develop a poorly understood hindlimb paresis that resolves upon cessation of antibiotic use. To provide the best experiences, we use technologies like cookies to store and/or access device information. Polymerase chain reaction (PCR) test for coronavirus disease 2019 (COVID-19) was negative, and influenza, mycoplasma, and Legionella antigen tests were also negative. Deleterious effects: infections of humans, animals and plants. They are also being investigated for therapeutic use against cancers such as melanoma and allergic conditions [19]. Note:Betamethasone is a potent steroid that can induce severe cutaneous atrophy if overused; its use should be restricted to less than 14 days, particularly on thin skin such as that on the abdomen. The ubiquitously present gram-negative bacteriaPantoea agglomerans is not a commonly known human pathogen. The site is secure. Humans get exposed by ingestion of infected plants or thorn pricks. Shampoos improve skin and coat quality as infection is resolved, and are considered superior to other topical therapies because many shampoos contain: Topical antibioticscan be used in some cases to help resolve MRS-associated pyodermas. Chest X-ray showed hyperinflation with mild perihilar congestion without any evidence of consolidation and no significant changes compared with the prior study. [26], Includes P. a. pv. Sequential Organ Failure Assessment (SOFA) score was less than 2 (less than 9 implies <33.3% mortality), and PaO2/FiO2 ratio was 260. Both Pag and P. a. pv. Emollients that help prevent drying of the skin, which can happen with other products, such as scrubs. 6 Dogs with atopic dermatitis are especially susceptible due to: A defective skin barrier, which is represented by the stratum corneum and one of the first physical and chemical defenses against . However, considering that tetracycline is no longer available, doxycycline or minocycline may be used instead. Pyoderma is a common skin disorder in small animal practice. The dominant presence of P. agglomerans (as high as 31.25%) has been reported in respiratory samples of immunocompromised patients presenting with respiratory symptoms, raising the possibility of its effect among patients with poorly controlled COPD with chronic exposure to steroids similar to our patient [12]. Bdard Mthot D, Leblanc , Lacasse Y. Proton pump inhibitors use is associated with a lower risk of acute exacerbation and mortality in patients with coexistent COPD and GERD. The patient endorsed ongoing nausea, vomiting, chest pain, body aches, headaches, and fever and was admitted for IV antibiotics and further workup. This species has been identified as a possible cause of equine abortion and placentitis and a haemorrhagic disease in dolphin fish (Coryphaena hippurus). Of all the species with which we work, dogs seem uniquely predisposed to bacterial skin infections. P. agglomerans strains occur commonly, usually as symbionts, in insects and other arthropods. Hence, therapeutic use of steroids in COPD can act as a double-edged sword; on one hand, helping acute exacerbation, while, on the other hand, leading to opportunistic infections such as P. agglomerans. Pantoea: insights into a highly versatile and diverse genus within the Enterobacteriaceae. 2010; De Maayer et al . Bathing helps to remove adherent crusts and sticky exudates, promoting drainage and drying. No convincing lung consolidation or acute infiltrate pleural effusion was noted, with normal mediastinum, heart size, and unremarkable hila with pericardial effusion (Figure (Figure11). Wash the rest of the dog and leave the shampoo on the skin for 10 minutes before rinsing. Based on shared protein homologs, it was previously classified in the Enterobacteriaceae family along with Klebsiella, Escherichia, Salmonella, and Enterobacter [6-8]. Most dermatologists believe that the most appropriate first-choice antibiotic for canine pyoderma is a cephalosporin and, in most patients, treatment with cephalosporins may be empirical. 8600 Rockville Pike Surgical excision may be curative in some cases of vulvar fold pyoderma and tail fold pyoderma in English bulldogs. Widespread occurrence and potential of inhalational transmission make P. agglomerans a possible cause ofCOPD exacerbations [23]. Commun Chem. Shubov A., Jagannathan P., Chin-Hong P. V. Pantoea agglomerans pneumonia in a heart-lung transplant recipient: case report and a review of an emerging pathogen in immunocompromised hosts. [8], Pantoea agglomerans has also been used as a biocontrol organism to manage other plant diseases, such as grapevine trunk disease caused by the fungal pathogen Neofusicoccum parvum. sharing sensitive information, make sure youre on a federal Introduction Otitis externa is an inflammation of the external auditory canal from the pinna to the tympanic membrane commonly observed in canine patients in small animal veterinary practice ( 1, 2 ). Liver function tests showed total bilirubin of 0.5 mg/dL,aspartate transaminase of 14 U/L, alanine transaminase of 13 U/L, alkaline phosphatase of 119 U/L, total protein of 5.9 g/dL, albumin of 3.7 m/dL, and elevated bicarbonate of 35.7 mEq/L. Pantoae agglomerans was isolated in one out of two blood cultures. Sulfamethoxine/ormetoprim is useful, as it can be administered once daily. with chlorhexidine shampoos and/or other topicals instead of systemic antibiotics whenever possible. In an otherwise healthy dog, blood analysis should occur before administration, then 10 to 14 days into therapy. Typically, the bacteria have low virulence and a mild clinical course, with timely antibiotic initiation resulting in a favorable outcome. The technical storage or access is required to create user profiles to send advertising, or to track the user on a website or across several websites for similar marketing purposes.
Inducible clindamycin-resistance in methicillin-resistant. eCollection 2022.
Francis M. J., Chin J., Lomiguen C. M., Glaser A. These lesions may, or may not, be pruritic; however, pruritus is usually quite profound in atopic dogs and pyoderma is a factor that escalates itch. She was switched to bilevel positive airway pressure (BiPAP) with inspiratory positive airway pressure/expiratory positive airway pressure of 15/5 mmHg, with a respiratory rate of 15 breaths per minute and FiO2 of 40% due to worsening respiratory status. Before Pantoea agglomerans is a Gram-negative facultatively anaerobic bacillus within the Enterobacteriaceae family [1]. Fitzgerald JR. Although many infections with P. agglomerans had specific identified sources such as plant materials, blood products, or intravenous fluids, it is unknown how this patient developed such a rare bloodstream infection. One indicator that this gene may be present is reported resistance to erythromycin, but sensitivity to clindamycin. However, this principle can no longer be applied in the age of staphylococcal methicillin resistanceonce the less active, beta-lactam antibiotics become ineffective, the entire class is useless for systemic therapy. She stated that she completed the prescribed 12-day course of levofloxacin, and although she still felt general fatigue and malaise, her fever had completely subsided. Since the creation of the new genus Pantoea in 1989, the evidence base available to neonatal health care providers is limited. It produces a number of antibiotics (herbicolin, pantocins .
Careers, Unable to load your collection due to an error. Safika S, Indrawati A, Afiff U, Hastuti YT, Zureni Z, Jati AP. van Damme CM, Willemse T, van Dijk A, et al. Pantoea dispersa (P dispersa) is a kind of the genus Pantoea, which is often isolated from plants, closely related to Erwinia. [12][13], Some strains of Pantoea agglomerans have been identified as the cause of leaf blight of rice in Korea and leaf blight of oats in China. S pseudintermedius, while not as virulent, shares many characteristics withS aureus, including: Methicillin-resistantS pseudintermedius(MRSP) is unlikely to cause human infection, unless a person is very young, very old, or immunocompromised. Knee Septic Arthritis Caused by Pantoea agglomerans. 2023 May 2;6(1):88. doi: 10.1038/s42004-023-00884-8. If the organism is sensitive, potentiated sulfonamides can be used. Methicillin resistance inStaphylococciis associated with acquisition of a gene, mecA, that is incorporated into the bacterial genome and subsequently passed on to all daughter cells.22-24. Without a subpoena, voluntary compliance on the part of your Internet Service Provider, or additional records from a third party, information stored or retrieved for this purpose alone cannot usually be used to identify you. the contents by NLM or the National Institutes of Health. To our knowledge, this is the first case report speculating the possibility of P. agglomerans as a potential contributing factor for the pathology of COPD.
INTRODUCTION. PMC CT: computed tomography; COPD: chronic obstructive pulmonary disease; GGO: ground-glass opacities. Walterson AM, Stavrinides J. Nissan G, Gershovits M, Morozov M, Chalupowicz L, Sessa G, Manulis-Sasson S, Barash I, Pupko T. Mol Plant Pathol. Lincosamides:If reported as sensitive, clindamycin can also be used, but only if the bacteria are sensitive to all macrolides.29A resistance factor, termed theclindamycin-inducible resistance factor, can be found inStaphylococcusspecies. This can occur when cotton is used to filter substances prior to intravenous injection. It should be noted that only about 20% of reportedcase reports and case series were able to isolate Pantoea species in two sets of blood cultures. SCCmec in Staphylococci: Genes on the move. It has been hypothesized that topical therapy may give bacteria time and opportunity to eject the resistance genes and become susceptible again (see. are required, treating with the appropriate dose until the pyoderma is completely resolved. [10], It is also commonly found as a symbiont in the gut of mosquitoes. [16] These properties include: "tumours,[17] hyperlipidaemia, diabetes,[18] ulcer, various infectious diseases, atopic allergy[19] and stress-induced immunosuppression". Revealing the inventory of type III effectors in Pantoea agglomerans gall-forming pathovars using draft genome sequences and a machine-learning approach.
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